The days of finding plenty of ammo at bargain prices will not return for a good long time.
It is often said that God helps those who help themselves. In these uncertain times the masses have long been helping themselves to guns and ammo wherever they can find it. The lines are getting longer and the supplies are limited. There is no end in sight.
This old model Ruger Vaquero single action .45 Colt "cowboy gun" can be quite formidable in the practiced hand of someone with a deliberate mindset. Cowboy style guns were being stripped from store shelves after everything else was taken. I never thought that would ever happen, but it has.
There never was a big demand (that I can recall) for high-end self defense loads for the .45 Colt. The photo above shows what I would use if I was down to it.
Not all of the ammo boxes in the photo above are full; I probably only have around 300-rounds total of a mixture of Colt .45 (AKA "long Colt") target, defense, and game loads. Not my top choice but it would serve better than having nothing at all.
Keep a cool head.
Practice safe gun handling and storage.
Peace be with you.