Most of my readily available home defense guns are .38 caliber revolvers, but three semi-automatic pistols also are on my top tier; the largest of those pistols is the compact Sig-239 9MM with Siglite night sights.
If I need to tuck it into my waistband, a Don Hume H715 clip holster is my choice. If I choose open carry, or semi-open carry with a shirttail or jacket hiding the gun, I use a Fobus Evolution paddle holster. Both holsters are very fast to put on and take off.
For personal defense, the 115-grain Federal 9BPLE +P+ load is my first choice for 9MM pistols, followed by the 124-grain +P Speer Gold Dot. I have enough of both to last the rest of my natural life.
The Sig-239 and the Glock-26 are as small as I care to go with a 9MM pistol, and they would be as large as I personally would choose for concealed carry if it were legal to do so in Illinois. I own both, and only marginally prefer the Sig to the Glock.